AP1G1
Description
The AP1G1 (adaptor related protein complex 1 subunit gamma 1) is a protein-coding gene located on chromosome 16.
AP-1 complex subunit gamma-1 is a protein that in humans is encoded by the AP1G1 gene. Adaptins are crucial components of clathrin-coated vesicles transporting ligand-receptor complexes from the plasma membrane or from the trans-Golgi network to lysosomes. The adaptin family of proteins is composed of four classes of molecules named alpha, beta-, beta prime- and gamma- adaptins. Adaptins, together with medium and small subunits, form a heterotetrameric complex called an adaptor, whose role is to promote the formation of clathrin-coated pits and vesicles. The protein encoded by this gene is a gamma-adaptin protein and it belongs to the adaptor complexes large subunits family. Two transcript variants encoding different isoforms have been found for this gene.
AP1G1, as part of the clathrin-associated adaptor protein complex 1 (AP-1), plays a crucial role in protein sorting within the late-Golgi/trans-Golgi network (TGN) and/or endosomes. AP complexes facilitate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. In association with AFTPH/aftiphilin in the aftiphilin/p200/gamma-synergin complex, AP1G1 participates in the trafficking of transferrin from early to recycling endosomes, as well as the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes.
AP1G1 is also known as ADTG, CLAPG1, USRISD.
