CARD11 : caspase recruitment domain family member 11
Description
The CARD11 gene provides instructions for making a protein called caspase recruitment domain-containing protein 11 (CARD11). This protein plays a crucial role in the immune system by acting as a signaling molecule, specifically in the activation of NF-κB, a transcription factor essential for immune responses. CARD11 is involved in the T cell receptor (TCR) and B cell receptor (BCR) signaling pathways, which are crucial for the activation and differentiation of T and B lymphocytes, respectively. These pathways are essential for mounting an effective immune response against pathogens.
Associated Diseases
- Immune deficiencies: Mutations in CARD11 can lead to various immune deficiencies, including severe combined immunodeficiency (SCID), which compromises the immune system‘s ability to fight infections.
- Autoimmune disorders: Dysregulation of CARD11 signaling has been implicated in autoimmune disorders such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA).
- Cancer: Aberrant CARD11 activity has been linked to the development of certain cancers, particularly lymphomas.
- Inflammatory diseases: CARD11 may contribute to inflammatory diseases like inflammatory bowel disease (IBD).
Did you know?
CARD11 is known as a ‘molecular switch‘ because it can toggle between an inactive and active state, regulating the flow of immune signaling.
