CD27
Description
The CD27 (CD27 molecule) is a protein-coding gene located on chromosome 12.
CD27 belongs to the tumor necrosis factor receptor superfamily and acts as a co-stimulatory immune checkpoint molecule. It is currently under investigation as a potential target for anti-cancer drugs. During mouse embryonic development, CD27 expression, along with other specific markers, defines the earliest definitive hematopoietic stem cells. CD27 is expressed on both naive and activated effector T cells, NK cells, and activated B cells. It is a type I transmembrane protein with cysteine-rich domains. Once T cells become activated, a soluble form of CD27 can be shed. CD27 binds to its ligand CD70, playing a crucial role in regulating B-cell activation and immunoglobulin synthesis. Upon CD27-CD70 binding, a signaling cascade is initiated, leading to T cell differentiation and clonal expansion. This cascade also enhances the survival and memory of cytotoxic T cells and increases the production of certain cytokines.
CD27 is a receptor for CD70/CD27L, potentially contributing to the survival of activated T cells. It may also play a role in apoptosis through its association with SIVA1.
CD27 is also known as S152, S152. LPFS2, T14, TNFRSF7, Tp55.
