CDC14A
Description
The CDC14A (cell division cycle 14A) is a protein-coding gene located on chromosome 1.
CDC14A is a human enzyme belonging to the dual specificity protein tyrosine phosphatase family. It is highly similar to the yeast protein Cdc14, which is involved in cell cycle control, suggesting a similar role in humans. CDC14A interacts with and dephosphorylates the tumor suppressor protein p53, potentially regulating its function. This gene produces 3 distinct isoforms due to alternative splicing. CDC14A dephosphorylates p53 at Serine 315, stabilizing p53. Phosphorylation of p53 at S315, unlike other phosphorylation sites, promotes p53 degradation.
CDC14A is a dual-specificity phosphatase that plays a crucial role in cell division. It is required for centrosome separation and productive cytokinesis. CDC14A dephosphorylates SIRT2 around early anaphase, potentially dephosphorylates the APC subunit FZR1/CDH1, promoting APC-FZR1 dependent degradation of mitotic cyclins and exit from mitosis. CDC14A is also essential for normal hearing.
CDC14A is also known as DFNB105, DFNB32, DFNB35, cdc14, hCDC14.
