F11 : coagulation factor XI
Description
The F11 gene, provides instructions for making a protein called coagulation factor XI. This protein is a crucial component of the intrinsic pathway, a complex cascade of reactions that leads to the formation of a blood clot. When a blood vessel is injured, the intrinsic pathway is activated, ultimately leading to the conversion of prothrombin to thrombin, which triggers the formation of a fibrin clot. This clot acts as a plug, preventing further blood loss.
Associated Diseases
- Hemophilia C (Factor XI deficiency): A rare bleeding disorder caused by a deficiency in factor XI. Individuals with Hemophilia C may experience prolonged bleeding after injury or surgery.
- Thrombosis (Blood clots): In some cases, mutations in the F11 gene may lead to increased factor XI activity, increasing the risk of blood clots in the arteries and veins. These clots can be life-threatening, potentially leading to heart attack, stroke, or pulmonary embolism.
Did you know?
Factor XI deficiency is more common in Ashkenazi Jewish populations compared to other ethnicities.
