Prader Willi

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Prader–Willi syndrome (PWS) is a rare genetic disorder caused by a loss of function of specific genes on chromosome 15. 

1. Symptoms in Newborns:

   • Weak muscles.
   • Poor feeding.
   • Slow development.

2. Childhood Symptoms:

   • Constant hunger, which often leads to obesity and type 2 diabetes.
   • Mild to moderate intellectual impairment.
   • Behavioral problems.

3. Physical Characteristics:

   • Narrow forehead.
   • Small hands and feet.
   • Short height.
   • Light skin and hair.
   • Most affected individuals are unable to have children.

4. Genetic Mechanisms:

   • Paternal deletion: About 74% of cases occur when part of the father’s chromosome 15 is deleted.