VPS37A
Description
The VPS37A (VPS37A subunit of ESCRT-I) is a protein-coding gene located on chromosome 8.
VPS37A is a human protein encoded by the VPS37A gene. It's a member of the ESCRT system, involved in sorting cellular components. A mutation (K382N) in VPS37A can cause complex hereditary spastic paraparesis (cHSP), a neurological disorder affecting movement.
VPS37A is part of the ESCRT-I complex, which controls how vesicles move within cells. It's crucial for sorting ubiquitinated cargo, destined for degradation, into multivesicular bodies. This protein may also play a role in cell growth and differentiation.
VPS37A is also known as HCRP1, PQBP2, SPG53.
