ABCB10
ABC B10: A Transporter Protein with Multifaceted Roles
Description
The ATP-binding cassette subfamily B member 10 (ABCB10) is a transmembrane protein that belongs to the ABC transporter superfamily. It is localized to the canalicular membrane of hepatocytes in the liver, where it plays a crucial role in the detoxification and transport of various molecules, including bile acids, phospholipids, steroids, and xenobiotics.
Associated Diseases
Dysfunction of ABCB10 has been implicated in several human diseases, including:
- Cholestasis: Impaired ABCB10 function can lead to decreased bile flow, resulting in cholestasis, a condition characterized by the buildup of bile in the liver and bile ducts.
- Intrahepatic cholestasis of pregnancy: This condition, which occurs specifically during pregnancy, involves impaired bile acid transport due to reduced ABCB10 activity.
- Progressive familial intrahepatic cholestasis: This rare genetic disorder is caused by mutations in the gene encoding ABCB10, leading to severe liver dysfunction and cirrhosis.
Did you Know ?
Over 30% of cases of intrahepatic cholestasis of pregnancy are attributed to reduced ABCB10 activity.
