ACLY
Description
The ACLY gene encodes ATP citrate lyase, a crucial enzyme involved in the synthesis of acetyl-CoA, a fundamental molecule in cellular metabolism. ACLY catalyzes the conversion of citrate, a product of the citric acid cycle, into acetyl-CoA and oxaloacetate. This reaction plays a central role in fatty acid biosynthesis, cholesterol synthesis, and other metabolic processes. ACLY expression and activity are tightly regulated, ensuring adequate acetyl-CoA supply for various cellular needs. Dysregulation of ACLY has been implicated in various metabolic disorders, including obesity, diabetes, and cancer.
Associated Diseases
- Obesity
- Type 2 diabetes
- Non-alcoholic fatty liver disease (NAFLD)
- Cancer (e.g., breast, prostate, colon)
- Metabolic syndrome
Did you know?
ACLY is a large enzyme complex, consisting of four subunits. It requires ATP, CoA, and citrate as substrates for its activity.
