ADAM3A
ADAM3A: A Key Player in Development and Disease
Description
ADAM3A (A disintegrin and metallopeptidase domain 3A) is a transmembrane protein with diverse roles in cellular processes. It is involved in cell adhesion, migration, signaling, and extracellular matrix remodeling. ADAM3A consists of an extracellular domain with a peptidase domain and a disintegrin domain, as well as a transmembrane domain and an intracellular domain.
Associated Diseases
ADAM3A has been implicated in various diseases, including:
- Musculoskeletal disorders: Osteoarthritis, rheumatoid arthritis, and osteoporosis
- Neurological disorders: Alzheimer‘s disease, Parkinson‘s disease, and multiple sclerosis
- Cardiovascular diseases: Atherosclerosis and heart failure
- Cancer: Breast cancer, prostate cancer, and colorectal cancer
- Skin disorders: Psoriasis and atopic dermatitis
Did you Know ?
Approximately 1 in 50 people carry a mutation in the ADAM3A gene, which can increase their risk of developing osteoarthritis.
