AGTRAP
Description
The AGTRAP (angiotensin II receptor associated protein) is a protein-coding gene located on chromosome 1.
AGTRAP (angiotensin II receptor-associated protein) is a human gene that encodes a transmembrane protein found in the plasma membrane and perinuclear vesicles. This protein interacts with the angiotensin II type I receptor and inhibits angiotensin II signaling. Alternative splicing of the gene generates various transcript variants leading to different isoforms. AGTRAP is known to interact with GNB2L1.
AGTRAP negatively regulates type-1 angiotensin II receptor-mediated signaling by influencing receptor internalization and desensitization mechanisms, such as phosphorylation. It also reduces cell proliferation and angiotensin II-stimulated gene expression.
AGTRAP is also known as ATRAP.
Associated Diseases
- cancer
- endometrial cancer
- familial idiopathic steroid-resistant nephrotic syndrome
- obesity due to melanocortin 4 receptor deficiency
- PLIN1-related familial partial lipodystrophy
- glomerulopathy with fibronectin deposits 2
- LIPE-related familial partial lipodystrophy
- CIDEC-related familial partial lipodystrophy
- nail-patella-like renal disease
- hemoglobin D disease
- focal segmental glomerulosclerosis 5
- X-linked sideroblastic anemia 1
- adenine phosphoribosyltransferase deficiency
- autosomal dominant progressive nephropathy with hypertension
