AIDA
Description
The AIDA (axin interactor, dorsalization associated) is a protein-coding gene located on chromosome 1.
AIDA is a human gene.
AIDA acts as a ventralizing factor during embryogenesis. It inhibits axin-mediated JNK activation by binding to axin and disrupting axin homodimerization. This action antagonizes a Wnt/beta-catenin-independent dorsalization pathway activated by AXIN/JNK-signaling.
AIDA is also known as C1orf80.
Associated Diseases
- coronary atherosclerosis
- obesity due to melanocortin 4 receptor deficiency
- LIPE-related familial partial lipodystrophy
- PLIN1-related familial partial lipodystrophy
- CIDEC-related familial partial lipodystrophy
- obesity due to prohormone convertase I deficiency
- familial partial lipodystrophy, Kobberling type
- PPARG-related familial partial lipodystrophy
