AKR1E2
Description
The AKR1E2 (aldo-keto reductase family 1 member E2) is a protein-coding gene located on chromosome 10.
AKR1E2 catalyzes the reduction of 1,5-anhydro-D-fructose (AF) to 1,5-anhydro-D-glucitol using NADPH as a cofactor. It also exhibits low reductase activity towards 9,10-phenanthrenequinone in vitro.
AKR1E2 is also known as AKR1CL2, AKRDC1, HTSP1, LoopADR, TAKR, hTSP, htAKR.
Associated Diseases
- retinoblastoma
- childhood testicular germ cell tumor
- cerebrotendinous xanthomatosis
- T-cell non-Hodgkin lymphoma
