ALDH2
Description
The ALDH2 gene encodes the mitochondrial aldehyde dehydrogenase 2 enzyme, a crucial component of the alcohol metabolism pathway. This enzyme converts acetaldehyde, a toxic byproduct of alcohol breakdown, into acetate, a less harmful compound. Variations in the ALDH2 gene can significantly impact alcohol tolerance, susceptibility to alcohol-related disorders, and overall health.
Associated Diseases
- Alcohol Dependence
- Alcohol-Related Liver Disease
- Esophageal Cancer
- Cardiovascular Disease
- Neurological Disorders
Did you know?
Individuals with a common ALDH2 gene variant (ALDH2*2) experience flushing, nausea, and rapid heartbeat after consuming even small amounts of alcohol. This is often referred to as the "Asian flush" and is thought to be a protective mechanism against excessive alcohol consumption.
