ALDH8A1
Description
The ALDH8A1 (aldehyde dehydrogenase 8 family member A1) is a protein-coding gene located on chromosome 6.
ALDH8A1, also known as Aldehyde dehydrogenase 8 family, member A1, is an enzyme encoded by the ALDH8A1 gene in humans. It belongs to the aldehyde dehydrogenase family and was initially believed to be involved in the biosynthesis of 9-cis-retinoic acid. However, further research indicated that it is more likely involved in the kynurenine pathway, specifically oxidizing 2-aminomuconate semialdehyde to 2-aminomuconic acid. This gene has two transcript variants encoding distinct isoforms.
This enzyme is involved in the kynurenine metabolic pathway, which is responsible for the breakdown of L-tryptophan. Specifically, it catalyzes the oxidation of 2-aminomuconic semialdehyde to 2-aminomuconic acid using NAD as a cofactor.
ALDH8A1 is also known as ALDH12, DJ352A20.2.
