ALG10
Description
The ALG10 (ALG10 alpha-1,2-glucosyltransferase) is a protein-coding gene located on chromosome 12.
The ALG10 gene encodes a membrane-bound protein that plays a vital role in the process of N-linked glycosylation. It acts as an alpha-1,2-glucosyltransferase, specifically adding the third glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. This enzyme transfers the terminal glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc2Man9GlcNAc(2)-PP-Dol. Interestingly, the rat homolog of this protein has been shown to modulate the gating function of the rat neuronal ether-a-go-go (EAG) potassium ion channel.
Adds the third and final glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. This enzyme transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(2)Man(9)GlcNAc(2)-PP-Dol.
ALG10 is also known as ALG10A, DIE2, KCR1.
Associated Diseases
- hearing loss, autosomal recessive
- autosomal dominant nonsyndromic hearing loss 7
- autosomal dominant nonsyndromic hearing loss 17
- deafness, aminoglycoside-induced
- autosomal dominant nonsyndromic hearing loss
- autosomal recessive nonsyndromic hearing loss 1B
- hearing loss, autosomal recessive 110
- autosomal dominant nonsyndromic hearing loss 40
- hearing loss, autosomal recessive 117
- hearing loss, autosomal dominant 74
- hearing loss, autosomal dominant 83
- autosomal dominant nonsyndromic hearing loss 3B
- hearing loss, sensorineural, autosomal-mitochondrial type
