ALG10B
Description
The ALG10B (ALG10 alpha-1,2-glucosyltransferase B) is a protein-coding gene located on chromosome 12.
ALG10B, also known as Alpha-1,2-glucosyltransferase ALG10-B, is an enzyme encoded by the ALG10B gene in humans. It belongs to the Dolichyl-P-Glc:Glc2Man9GlcNAc2-PP-dolichol alpha-1,2-glucosyltransferase class of enzymes. ALG10B is ubiquitously expressed in 27 tissues.
ALG10B is a putative alpha-1,2-glucosyltransferase responsible for adding the third glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. It transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(2)Man(9)GlcNAc(2)-PP-Dol (By similarity). When coupled with KCNH2, ALG10B may reduce KCNH2 sensitivity to classic proarrhythmic drug blockade, possibly by mediating glycosylation of KCNH2 (PubMed:14525949). ALG10B plays a role in maintaining cochlear outer hair cell function (By similarity). {ECO:0000250|UniProtKB:P50076, ECO:0000250|UniProtKB:Q3UGP8, ECO:0000269|PubMed:14525949}.
ALG10B is also known as ALG10, KCR1.
