ANO4

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Description

The ANO4 (anoctamin 4) is a protein-coding gene located on chromosome 12.

ANO4 acts as a calcium-dependent phospholipid scramblase, facilitating the movement of lipids like phosphatidylserine, phosphatidylcholine, and galactosylceramide across cell membranes. However, it does not exhibit the characteristic calcium-activated chloride channel (CaCC) activity.

ANO4 is also known as TMEM16D.

Associated Diseases

• COVID-19
• substance abuse
• schizophrenia 15
• Phelan-McDermid syndrome
• Adams-Oliver syndrome