ARL1
Description
The ARL1 (ADP ribosylation factor like GTPase 1) is a protein-coding gene located on chromosome 12.
ARL1, also known as ADP-ribosylation factor-like protein 1, is a protein encoded by the ARL1 gene in humans. It belongs to the ARL family of proteins, which are structurally similar to ADP-ribosylation factors (ARFs). ARFs regulate intracellular vesicular membrane trafficking and stimulate a phospholipase D (PLD) isoform. While ARL proteins were initially believed to lack CT or PLD activation capabilities, further research revealed their weak stimulation of PLD and CT in a phospholipid-dependent manner. ARL1 interacts with GOLGA4 and GOLGA1.
ARL1, a GTP-binding protein, recruits various effectors including golgins, arfaptins, and Arf-GEFs to the trans-Golgi network, regulating their functions at the Golgi complex. This process is vital for several fundamental cellular processes, such as cell polarity, innate immunity, and protein secretion. Specifically, arfaptins play a role in maintaining insulin secretion from pancreatic beta cells.
ARL1 is also known as ARFL1.
