ASAP1
Description
The ASAP1 (ArfGAP with SH3 domain, ankyrin repeat and PH domain 1) is a protein-coding gene located on chromosome 8.
ASAP1 acts as a GTPase-activating protein (GAP) for ARF1, ARF5, and to a lesser extent ARF6. Its activity is dependent on the presence of phosphatidylinositol 4,5-bisphosphate (PIP2). ASAP1 plays a role in coordinating membrane trafficking with cell growth and actin cytoskeleton remodeling by binding to SRC and PIP2. Additionally, it may function as a signal transduction protein involved in the differentiation of fibroblasts into adipocytes and potentially other cell types. ASAP1 is a component of the ciliary targeting complex, which also includes Rab11, Rabin8/RAB3IP, RAB11FIP3, and ARF4. This complex directs preciliary vesicle trafficking to the mother centriole, initiating ciliogenesis.
ASAP1 is also known as AMAP1, CENTB4, DDEF1, PAG2, PAP, ZG14P.
