ASB8
Description
The ASB8 (ankyrin repeat and SOCS box containing 8) is a protein-coding gene located on chromosome 12.
ASB8 acts as a substrate-recognition component within a specific type of E3 ubiquitin ligase complex called SCF-like ECS. This complex is responsible for tagging target proteins with ubiquitin, marking them for degradation by the proteasome.
ASB8 is also known as PP14212.
Associated Diseases
- X-linked retinal dysplasia
- retinitis pigmentosa
- choroidal dystrophy, central areolar, 1
- severe early-childhood-onset retinal dystrophy
- reticular dystrophy of the retinal pigment epithelium
- age related macular degeneration 7
- age related macular degeneration 11
- age related macular degeneration 4
- Leber congenital amaurosis
