ASMTL
Description
The ASMTL (acetylserotonin O-methyltransferase like) is a protein-coding gene located on chromosome X|Y.
The ASMTL gene encodes for N-acetylserotonin O-methyltransferase-like protein, an enzyme found in humans.
ASMTL is a nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. It can also hydrolyze CTP and modified nucleotides like pseudo-UTP, 5-methyl-UTP (m(5)UTP), and 5-methyl-CTP (m(5)CTP). ASMTL exhibits weak activity against dCTP, 8-oxo-GTP, and N(4)-methyl-dCTP. This enzyme likely plays a role in cell division arrest and preventing the incorporation of modified nucleotides into cellular nucleic acids. Additionally, the presence of a putative catalytic domain for S-adenosyl-L-methionine binding in the C-terminal region suggests a potential methyltransferase activity.
ASMTL is also known as ASMTLX, ASMTLY, ASTML.
Associated Diseases
- cancer
- Alzheimer disease
- breast cancer
- hypophosphatasia
- Bartsocas-Papas syndrome 1
- Turner syndrome
- Timothy syndrome
- microphthalmia with limb anomalies
