ATXN1L
Description
The ATXN1L (ataxin 1 like) is a protein-coding gene located on chromosome 16.
ATXN1L acts as a corepressor for the CBF1 transcription factor, suppressing Notch signaling when the Notch intracellular domain is absent. It binds to the HEY promoter and potentially aids in RBPJ-mediated repression along with NCOR2. ATXN1L can counteract the toxic effects of ATXN1 in spinocerebellar ataxia type 1 (SCA1). It plays a role in brain development in collaboration with CIC and ATXN1.
ATXN1L is also known as BOAT, BOAT1.
