BATF2
Description
The BATF2 (basic leucine zipper ATF-like transcription factor 2) is a protein-coding gene located on chromosome 11.
BATF2, short for Basic leucine zipper transcription factor, ATF-like 2, is a protein encoded by the BATF2 gene in humans.
BATF2 is a transcription factor that plays a critical role in the immune system by regulating the differentiation of specialized immune cells. It forms a complex with JUN family proteins, binding to specific DNA sequences (5'-TGA[CG]TCA-3') to control the expression of target genes. BATF2 is particularly important in the development of CD8+ thymic conventional dendritic cells, which are crucial for immune responses to infections. Additionally, BATF2 acts as a tumor suppressor by inhibiting the expression of CCN1, a protein involved in cell proliferation and tumor growth. This inhibition prevents the development of anchorage-independent growth and invasion in various cancer types, such as breast cancer, glioma, and melanoma.
BATF2 is also known as SARI.
