BAZ1A
Description
The BAZ1A (bromodomain adjacent to zinc finger domain 1A) is a protein-coding gene located on chromosome 14.
BAZ1A (Bromodomain adjacent to zinc finger domain protein 1A) is a protein encoded by the BAZ1A gene in humans. It belongs to a family of proteins including BAZ1B, BAZ2A, and BAZ2B, all sharing common structural domains: an N-terminal PHD finger (C4HC3 zinc finger), a WAKZ motif, an LH (leucine-rich helical domain) motif, and a C-terminal bromodomain. BAZ1A forms part of the WCRF/CHRAC ATP-dependent chromatin-remodeling complex along with SMARCA5, POLE3, and CHRAC1. This complex can organize nucleosomes into a regularly spaced array in an ATP-dependent manner. Notably, the BAZ1A-SMARCA5 complex facilitates DNA replication through dense chromatin regions. BAZ1A has been observed to interact with SMARCA5 and SATB1.
BAZ1A is a regulatory subunit of the ATP-dependent ACF-1 and ACF-5 ISWI chromatin remodeling complexes. These complexes help organize nucleosomes on chromatin, moving them to more accessible positions on the DNA template. This facilitates important DNA-related processes such as replication, transcription, and repair. Both complexes regulate the spacing of nucleosomes along the chromatin and can reposition mononucleosomes to the center of a DNA template using ATP. ACF-1 has a slower ATP hydrolysis rate compared to ACF-5. BAZ1A plays a role in sensing the length of DNA flanking nucleosomes, which affects the nucleosome spacing activity of the ACF-5 complex. It is involved in DNA replication and, together with SMARCA5/SNF2H, is required for the replication of pericentric heterochromatin in S-phase. BAZ1A may also be involved in nuclear receptor-mediated transcription repression.
BAZ1A is also known as ACF1, WALp1, WCRF180, hACF1.
