BCL3
Description
The BCL3 (BCL3 transcription coactivator) is a protein-coding gene located on chromosome 19.
BCL3 is a protein encoded by the BCL3 gene, a proto-oncogene candidate. It is characterized by seven ankyrin repeats, similar to those found in I kappa B proteins. BCL3 functions as a transcriptional coactivator, activating through its association with NF-kappa B homodimers. Its expression can be induced by NF-kappa B, forming an autoregulatory loop controlling the nuclear residence of p50 NF-kappa B. BCL3 has been implicated in various cancers, including lymphoma, and is associated with late-onset Alzheimer's disease (LOAD) and chronic lymphocytic leukemia. Increased BCL3 expression is observed in the brains of LOAD patients. Notably, BCL3 promotes metastasis in ErbB2-positive breast cancer without affecting primary tumor growth or normal mammary function.
BCL3 regulates the transcriptional activation of NF-kappa-B target genes. In the cytoplasm, it inhibits the nuclear translocation of the NF-kappa-B p50 subunit. However, in the nucleus, it acts as a transcriptional activator promoting transcription of NF-kappa-B target genes. BCL3 also contributes to the regulation of cell proliferation.
BCL3 is also known as BCL4, D19S37.
