BEND3
Description
The BEND3 (BEN domain containing 3) is a protein-coding gene located on chromosome 6.
BEND3 is a transcriptional repressor that associates with the NoRC (nucleolar remodeling complex) complex and plays a key role in repressing rDNA transcription. The sumoylated form of BEND3 modulates the stability of the NoRC complex component BAZ2A/TIP5 by controlling its USP21-mediated deubiquitination. BEND3 binds to unmethylated major satellite DNA and is involved in the recruitment of the Polycomb repressive complex 2 (PRC2) to major satellites. It stimulates the ERCC6L translocase and ATPase activities.
BEND3 is also known as KIAA1553.
