C5AR2
Description
The C5AR2 (complement C5a receptor 2) is a protein-coding gene located on chromosome 19.
C5AR2 is a protein involved in the complement system, encoded by the C5AR2 gene. It is highly expressed in blood and spleen, primarily by myeloid cells. It is a receptor for the anaphylatoxins C3a and C5a, fragments of C3 and C5 generated during the complement cascade. C5AR2 was initially thought to be a decoy receptor, but recent research has uncovered independent roles, including modulation of the innate immune response in myeloid cells, translocation of C5a to drive neutrophil migration, β-arrestin recruitment, modulation of ERK signaling, and modulation of lipid metabolism in obesity. It is implicated in inflammatory and infectious diseases.
C5AR2 is a receptor for the chemotactic and inflammatory anaphylatoxin peptides C3a, C4a, and C5a, as well as their des-arginine forms (ASP/C3adesArg, C4adesArg, and C5adesArg). It weakly couples to G(i)-mediated signaling pathways.
C5AR2 is also known as C5L2, GPF77, GPR77.
Associated Diseases
- ovarian cancer
- X-linked severe congenital neutropenia
- myeloperoxidase deficiency
- nonimmune chronic idiopathic neutropenia of adults
- neutropenia, severe congenital, 2, autosomal dominant
- cancer
- PLIN1-related familial partial lipodystrophy
- eosinophil peroxidase deficiency
- CIDEC-related familial partial lipodystrophy
- autosomal recessive severe congenital neutropenia due to CSF3R deficiency
- neutropenia-monocytopenia-deafness syndrome
- linear and whorled nevoid hypermelanosis
- X-linked sideroblastic anemia 1
- neutropenia, severe congenital, 1, autosomal dominant
