C9orf91
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<title>c9orf91: A Gene with Intriguing Roles in Health and Disease</title>
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<h1>c9orf91: A Gene with Intriguing Roles in Health and Disease</h1>
<h2>Description</h2>
c9orf91 is a gene located on chromosome 9 that encodes a protein of unknown function. The protein is predicted to be 1,246 amino acids long and contain several domains, including a zinc finger domain and a leucine zipper domain.
<h2>Associated Diseases</h2>
Mutations in c9orf91 have been linked to several diseases, including:
* <strong>Amyotrophic lateral sclerosis (ALS)</strong>: ALS is a neurodegenerative disease that affects the motor neurons in the brain and spinal cord. Mutations in c9orf91 are the most common genetic cause of ALS, accounting for about 5% of cases.
* <strong>Frontotemporal dementia (FTD)</strong>: FTD is a neurodegenerative disease that affects the frontal and temporal lobes of the brain. Mutations in c9orf91 are the most common genetic cause of FTD, accounting for about 10% of cases.
* <strong>Charcot-Marie-Tooth disease (CMT)</strong>: CMT is a group of inherited neurodegenerative diseases that affect the peripheral nerves. Mutations in c9orf91 have been linked to a rare form of CMT known as CMT4C.
* <strong>Myeloid leukemia</strong>: Mutations in c9orf91 have been linked to a rare type of myeloid leukemia known as acute myeloid leukemia (AML).
**Did you Know ?**
A study published in the journal Nature Genetics found that mutations in c9orf91 are present in about 5% of people with ALS and 10% of people with FTD. This makes c9orf91 one of the most common genetic causes of these diseases.
