CALCR
Calcitonin Gene-Related Peptide (CGRP)
Description:
Calcitonin gene-related peptide (CGRP) is a neuropeptide that plays a vital role in various physiological processes. Primarily produced by sensory neurons in the central and peripheral nervous systems, CGRP functions as a vasodilator, influencing blood flow and blood pressure regulation.
Associated Diseases:
CGRP dysregulation has been linked to several diseases, including:
- Migraine: CGRP levels spike during migraine attacks, causing inflammation and dilation of blood vessels in the brain.
- Cluster Headache: Elevated CGRP levels contribute to the intense, episodic pain associated with cluster headaches.
- Trigeminal Neuralgia: CGRP is involved in the transmission of sensory pain signals in trigeminal neuralgia.
- Osteoarthritis: CGRP may promote the inflammatory response in osteoarthritis, leading to cartilage damage and joint pain.
Did you Know ?
A study published in "Neurology" found that people with migraine had significantly higher levels of CGRP in their cerebrospinal fluid (CSF) than those without migraine.
