CAMLG
Description
The CAMLG (calcium modulating ligand) is a protein-coding gene located on chromosome 5.
CAMLG is a signaling protein that interacts with the TNF receptor TACI. It functions similar to the immunosuppressant drug cyclosporin A, binding to cyclophilin B and promoting calcium influx downstream of the T-cell receptor (TCR) and upstream of calcineurin. This integral membrane protein is involved in the calcium signal transduction pathway and potentially implicates cyclophilin B in calcium signaling.
CAMLG is essential for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum (ER). It acts as a membrane receptor, alongside GET1/WRB, for soluble GET3/TRC40, which recognizes and binds the transmembrane domain of TA proteins in the cytosol. CAMLG is critical for the stability of GET1 and plays a role in stimulating calcium signaling in T cells by elevating intracellular calcium. Furthermore, it is essential for the survival of peripheral follicular B cells.
CAMLG is also known as CAML, CDG2Z, GET2.
