CAND1
Description
The CAND1 (cullin associated and neddylation dissociated 1) is a protein-coding gene located on chromosome 12.
CAND1, or Cullin-associated NEDD8-dissociated protein 1, is a human protein encoded by the CAND1 gene. It has been shown to interact with various proteins, including but not limited to those involved in the SCF complex.
CAND1 is a key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes. It promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a crucial role in the cellular repertoire of SCF complexes. CAND1 acts as a F-box protein exchange factor, with its exchange activity coupled to cycles of neddylation conjugation. In the deneddylated state, cullin-binding CAND1 binds CUL1-RBX1, leading to increased dissociation of the SCF complex and facilitating the exchange of the F-box protein. CAND1 likely plays a similar role in other cullin-RING E3 ubiquitin ligase complexes.
CAND1 is also known as TIP120, TIP120A.
