CARD14 : caspase recruitment domain family member 14
Description
The CARD14 (caspase recruitment domain family member 14) is a protein-coding gene located on chromosome 17.
The CARD14 gene provides instructions for making a protein that activates a group of interacting proteins known as nuclear factor-kappa-B (NF-κB). NF-κB regulates the activity of genes controlling the body's immune responses and inflammatory reactions. Inflammation is a normal immune response to injury and foreign invaders. NF-κB also protects cells from signals that would otherwise cause them to self-destruct (apoptosis). The CARD14 protein is found in many tissues, particularly abundant in the skin. NF-κB signaling plays important roles in regulating inflammatory reactions in the skin and promoting the survival of skin cells.
CARD14 acts as a scaffolding protein, activating the inflammatory transcription factor NF-kappa-B and the p38/JNK MAP kinase signaling pathways. It forms a complex with BCL10 and MALT1, triggering MALT1's proteolytic activity and inflammatory gene expression. MALT1 is crucial for CARD14-mediated activation of NF-kappa-B and p38/JNK MAP kinases. CARD14 may also play a role in signaling mediated by TRAF2, TRAF3, and TRAF6, contributing to cell protection against apoptosis.
CARD14 is also known as BIMP2, CARMA2, PRP, PSORS2, PSS1.
Associated Diseases
- Pityriasis rubra pilaris
- Psoriasis 2
- Psoriatic arthritis
- Familial pityriasis rubra pilaris
- Generalized pustular psoriasis
