CCNE2
ccne2: Delving into a Critical Gene and its Impact on Human Health
Description
ccne2, also known as cyclin E2, is a crucial gene that plays a pivotal role in cell cycle regulation. It serves as a key component in controlling the transition from the G1 (growth phase) to the S (synthesis phase) of the cell cycle, which is essential for cell division and growth.
Associated Diseases
ccne2 gene mutations have been implicated in various diseases, including:
- Renal cell carcinoma (RCC): Mutations in ccne2 have been found to promote RCC development. In particular, overexpression of ccne2 has been linked to more aggressive RCC tumors.
- Ovarian cancer: ccne2 mutations have also been associated with ovarian cancer. They have been identified in up to 10% of high-grade serous ovarian cancers.
- Endometrial cancer: ccne2 overexpression has been observed in endometrial cancer, suggesting its role in promoting tumor growth and progression.
- Hepatocellular carcinoma (HCC): Elevated ccne2 levels have been detected in HCC and may contribute to tumor cell proliferation and survival.
- Glioblastoma (GBM): ccne2 alterations have been associated with GBM, particularly in the mesenchymal subtype.
Did you Know ?
- Mutations in ccne2 are estimated to occur in approximately 10-15% of RCC cases, making it one of the most frequently mutated genes in this cancer type.
