CCRN4L
CCR4L: A Receptor with Implications in Immunity and Disease
Description
CCR4L, or chemokine (C-C motif) receptor 4-like, is a protein that serves as a receptor for chemokines, small proteins involved in immune cell trafficking. It belongs to the G protein-coupled receptor (GPCR) superfamily and is closely related to CCR4.
Associated Diseases
CCR4L has been implicated in regulating immune responses and is associated with various diseases, including:
- Eosinophilic Esophagitis (EoE): CCR4L is highly expressed in the esophageal mucosa of EoE patients, contributing to eosinophil infiltration and inflammation.
- Atopic Dermatitis: CCR4L deficiency in animal models resulted in reduced skin inflammation and improved symptoms of atopic dermatitis.
- Allergic Rhinitis: CCR4L is involved in the recruitment of eosinophils and T helper type 2 (Th2) cells, which contribute to allergic responses in nasal mucosa.
- Asthma: CCR4L expression is increased in asthmatic airways, suggesting a role in Th2-mediated inflammation and airway remodeling.
Did you Know ?
Studies have shown that individuals with a deficiency in CCR4L have a significantly lower risk of developing EoE. In one study, only 0.5% of patients with CCR4L deficiency had EoE, compared to 5% of patients with normal CCR4L expression.
