CD52
Description
The CD52 (CD52 molecule) is a protein-coding gene located on chromosome 1.
CD52, or CAMPATH-1 antigen, is a glycoprotein found on the surface of mature lymphocytes, monocytes, and dendritic cells. It is also present in the male genital tract, particularly on mature sperm cells. This 12-amino-acid peptide, anchored to glycosylphosphatidylinositol (GPI), is highly negatively charged and may function in preventing cell adhesion, facilitating their movement. CD52 binds to SIGLEC10, a sialic acid-binding lectin containing an ITIM (immunoreceptor tyrosine-based inhibitory motif). CD52 is associated with certain types of lymphoma. Alemtuzumab, a monoclonal antibody targeting CD52, is used to treat chronic lymphocytic leukemia and organ transplantation. Clinical trials indicate that alemtuzumab, as a first-line therapy for relapsing-remitting multiple sclerosis, can reduce relapse rates, but not necessarily accumulated disability.
CD52 is also known as CDW52, EDDM5, HE5.
