CD6
Description
The CD6 (CD6 molecule) is a protein-coding gene located on chromosome 11.
CD6 (Cluster of Differentiation 6) is a human protein encoded by the CD6 gene. It is found on the outer membrane of T-lymphocytes and other immune cells. CD6 contains three scavenger receptor cysteine-rich (SRCR) domains and a binding site for an activated leukocyte cell adhesion molecule. It is important for continuation of T cell activation. Certain alleles of this gene may be associated with susceptibility to multiple sclerosis.
CD6 is a cell adhesion molecule that mediates cell-cell contacts and regulates T-cell responses through its interaction with ALCAM/CD166. It contributes to signaling cascades triggered by activation of the TCR/CD3 complex, functions as a costimulatory molecule promoting T-cell activation and proliferation, and contributes to the formation and maturation of the immunological synapse. CD6 acts as a calcium-dependent pattern receptor that binds and aggregates both Gram-positive and Gram-negative bacteria. It binds lipopolysaccharide (LPS) from Gram-negative bacteria and lipoteichoic acid from Gram-positive bacteria, activating signaling cascades and downstream MAP kinases, and mediating the activation of the inflammatory response and the secretion of pro-inflammatory cytokines in response to LPS.
CD6 is also known as TP120.
Associated Diseases
- multiple sclerosis
- graft versus host disease
- COVID-19
- cancer
- type 1 diabetes mellitus
- common variable immunodeficiency
- isolated agammaglobulinemia
