CD72
Description
The CD72 (CD72 molecule) is a protein-coding gene located on chromosome 9.
CD72 (Cluster of Differentiation 72), also known in murine biology as Lyb-2, is a protein active in the immune system of animals. It consists of two identical halves, each of about 39-43 kD, and is a C-type lectin. Its primarily locus of expression is B-cells (from the pro-B through the mature B-cell stage), where it appears to mediate aspects of B-cell - T-cell interaction. It is a ligand for CD5. CD72 is a regulatory protein on B lymphocytes. The cytoplasmic tail of CD72 contains two potential immunoreceptor tyrosine-based inhibitory motifs, one of which has been shown to recruit the tyrosine phosphatase SHP- 1. These features suggest a negative regulatory role for CD72. CD72 is a nonredundant regulator of B-cell development and a negative regulator of B-cell responsiveness.
CD72 is involved in B-cell development and proliferation.
CD72 is also known as CD72b, LYB2.
Associated Diseases
- common variable immunodeficiency
- isolated agammaglobulinemia
- immunodeficiency 62
- immunodeficiency 72 with autoinflammation
- combined immunodeficiency with skin granulomas
- BENTA disease
- combined immunodeficiency due to ZAP70 deficiency
- severe combined immunodeficiency due to CARD11 deficiency
- inborn error of immunity
- immunodeficiency 73c with defective neutrophil chemotaxis and hypogammaglobulinemia
- severe combined immunodeficiency due to CTPS1 deficiency
- severe combined immunodeficiency due to LAT deficiency
- immunodeficiency 18
- hyper-IgM syndrome type 3
- immunodeficiency 105
- T-B+ severe combined immunodeficiency due to JAK3 deficiency
- immunodeficiency 99 with hypogammaglobulinemia and autoimmune cytopenias
- severe combined immunodeficiency due to IKK2 deficiency
