CDCA7L
Description
The CDCA7L (cell division cycle associated 7 like) is a protein-coding gene located on chromosome 7.
Cell division cycle-associated 7-like protein (CDCA7L) is a protein encoded by the CDCA7L gene in humans. It plays a role in transcriptional regulation as a repressor. CDCA7L also plays an important oncogenic role in mediating the full transforming effect of MYC in medulloblastoma cells. It is involved in apoptotic signaling pathways.
CDCA7L acts as a transcriptional repressor, inhibiting monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter. It plays a critical oncogenic role, mediating the full transforming effect of MYC in medulloblastoma cells. CDCA7L participates in apoptotic signaling pathways, potentially acting downstream of P38-kinase and BCL-2, but upstream of CASP3/caspase-3, CCND1/cyclin D1, and E2F1. (PMID:15654081, PMID:15994933, PMID:16829576)
CDCA7L is also known as JPO2, R1, RAM2.
Associated Diseases
- primary ciliary dyskinesia
- situs inversus
- AL amyloidosis
- Miyoshi myopathy
- familial apolipoprotein C-II deficiency
