CDNF
Description
The CDNF (cerebral dopamine neurotrophic factor) is a protein-coding gene located on chromosome 10.
CDNF is a gene that encodes a protein involved in the growth and survival of dopamine neurons in the brain. It may also be known as ARMET-like protein 1 or Conserved dopamine neurotrophic factor.
CDNF is a trophic factor that promotes the survival and function of dopamine neurons. It protects these neurons from damage caused by 6-hydroxydopamine (6-OHDA), a toxin that is commonly used to model Parkinson's disease. When administered after 6-OHDA-induced damage, CDNF can restore dopamine function and prevent further degeneration of these neurons in the substantia nigra.
CDNF is also known as ARMETL1.
Associated Diseases
- X-linked retinal dysplasia
- retinitis pigmentosa
- Huntington disease
- severe early-childhood-onset retinal dystrophy
- choroidal dystrophy, central areolar, 1
- reticular dystrophy of the retinal pigment epithelium
- age related macular degeneration 4
- age related macular degeneration 7
- age related macular degeneration 11
- patterned macular dystrophy 3
- X-linked retinoschisis
