CELSR1
Description
The CELSR1 (cadherin EGF LAG seven-pass G-type receptor 1) is a protein-coding gene located on chromosome 22.
CELSR1, also known as Cadherin EGF LAG seven-pass G-type receptor 1, Flamingo homolog 2, or Cadherin family member 9, is a protein encoded by the CELSR1 gene in humans. It belongs to the flamingo subfamily of cadherins, which are non-classic cadherins that do not interact with catenins. These proteins are located on the cell membrane and contain nine cadherin domains, seven epidermal growth factor-like repeats, and two laminin G-like domains in their extracellular region. They also possess seven transmembrane domains, a unique characteristic of this subfamily. CELSR1 is thought to be a receptor involved in contact-mediated communication, with its cadherin domains acting as homophilic binding regions and its EGF-like domains participating in cell adhesion and receptor-ligand interactions. It is a developmentally regulated, neural-specific gene that plays an unknown role in early embryonic development.
CELSR1 is a receptor that plays a crucial role in cell-to-cell communication during the development of the nervous system.
CELSR1 is also known as ADGRC1, CDHF9, FMI2, HFMI2, LMPHM9, ME2.
