CELSR2
Description
The CELSR2 (cadherin EGF LAG seven-pass G-type receptor 2) is a protein-coding gene located on chromosome 1.
Cadherin EGF LAG seven-pass G-type receptor 2 (CELSR2) is a protein encoded by the CELSR2 gene in humans. It belongs to the flamingo subfamily of cadherins, which are non-classic cadherins that don't interact with catenins. Flamingo cadherins are located at the cell membrane and have a unique structure with nine cadherin domains, seven epidermal growth factor-like repeats, and two laminin A G-type repeats in their extracellular region. They also have seven transmembrane domains, a feature exclusive to this subfamily. These proteins are thought to act as receptors involved in cell-to-cell communication, with their cadherin domains serving as homophilic binding regions and their EGF-like domains participating in cell adhesion and receptor-ligand interactions. The specific function of CELSR2 is not yet fully understood.
This receptor likely plays a crucial role in communication between cells during the development of the nervous system.
CELSR2 is also known as ADGRC2, CDHF10, EGFL2, Flamingo1, MEGF3.
