CIRBP
Description
The CIRBP (cold inducible RNA binding protein) is a protein-coding gene located on chromosome 19.
Cold-inducible RNA-binding protein (CIRBP) is a protein encoded by the CIRBP gene in humans. It plays a crucial role in controlling the cellular response to various cellular stresses, such as short wavelength ultraviolet light, hypoxia, and hypothermia.
CIRBP is a cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. It acts as a translational activator and seems to be crucial for suppressing cell proliferation in cold conditions. CIRBP binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN, acting as a translational repressor. When overexpressed, it promotes the assembly of stress granules (SGs).
CIRBP is also known as CIRP.
