CLEC10A
Description
The CLEC10A (C-type lectin domain containing 10A) is a protein-coding gene located on chromosome 17.
CLEC10A, also known as CD301, is a protein encoded by the CLEC10A gene. It belongs to the C-type lectin superfamily and binds to N-Acetylgalactosamine (GalNAc). It's primarily expressed on myeloid cells, as well as oocytes and early stages of embryogenesis, serving as a marker for the CD1c+ dendritic cell subgroup (cDC2). CLEC10A's functions vary depending on the ligand and environment. C-type lectins generally bind carbohydrates in the presence of Ca2+ and participate in cell adhesion, signaling, glycoprotein turnover, and immune responses. CLEC10A is a type II transmembrane protein that triggers endocytosis after ligand binding. This involves the release of Ca2+ ions from the endosome, leading to increased cytoplasmic Ca2+ concentration. CLEC10A exhibits a strong preference for N-Acetylgalactosamine (GalNAc), particularly α-GalNAc over β-GalNAc, with minimal binding to unmodified galactose.
CLEC10A is also known as CD301, CLECSF13, CLECSF14, HML, HML2, MGL.
Associated Diseases
- endometrial cancer
- primary familial polycythemia due to EPO receptor mutation
- breast cancer
- hereditary persistence of fetal hemoglobin-sickle cell disease syndrome
- beta-thalassemia-X-linked thrombocytopenia syndrome
- alpha-thalassemia-myelodysplastic syndrome
- alpha thalassemia-intellectual disability syndrome type 1
- hemolytic anemia due to diphosphoglycerate mutase deficiency
- common variable immunodeficiency
- hemoglobin D disease
