CLEC2D
Description
The CLEC2D (C-type lectin domain family 2 member D) is a protein-coding gene located on chromosome 12.
The CLEC2D gene encodes a protein belonging to the natural killer cell receptor C-type lectin family. This protein inhibits osteoclast formation and has a transmembrane domain near its N-terminus and a C-type lectin-like extracellular domain. Multiple alternatively spliced transcript variants have been found, but their full-length nature remains unclear. CLEC2D encodes the Lectin Like Transcript-1 (LLT1) protein, which serves as a functional ligand for the human NKR-P1A receptor, encoded by the KLRB1 gene. In mice, several orthologs of the CLEC2D gene exist, with Clr-b/Ocil (Clec2d) being the presumed homolog. Clr-b has been linked to missing-self recognition by natural killer cells through its interaction with the NKR-P1B receptor.
CLEC2D acts as a receptor for KLRB1, shielding cells from destruction by natural killer cells. It also suppresses osteoclast formation, hindering bone resorption, and modulates interferon-gamma release. CLEC2D binds to high molecular weight sulfated glycosaminoglycans.
CLEC2D is also known as CLAX, LLT1, OCIL.
Associated Diseases
- multiple sclerosis
- type 1 diabetes mellitus
- upper respiratory tract disorder
- nonpapillary renal cell carcinoma
- familial idiopathic steroid-resistant nephrotic syndrome
- Eiken syndrome
