CLINT1
Description
The CLINT1 (clathrin interactor 1) is a protein-coding gene located on chromosome 5.
CLINT1, also known as EPSIN4, is a protein involved in clathrin-mediated vesicle trafficking. It binds to the terminal domain of the clathrin heavy chain, stimulating clathrin cage vesicle assembly. Clathrin-coated vesicles are crucial for the endocytosis of neurotransmitter receptors and other proteins across neuronal and other cell membranes. This process helps maintain a turnover of these proteins, allowing for fine-tuning of receptor numbers. Research suggests that CLINT1 may be involved in the genetic basis of schizophrenia. Antipsychotic drugs like chlorpromazine and clozapine stabilize clathrin-coated vesicles, potentially contributing to their effectiveness in treating schizophrenia symptoms.
CLINT1 binds to membranes enriched with phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). It may play a role in transporting cargo via clathrin-coated vesicles from the trans-Golgi network to endosomes. CLINT1 also stimulates clathrin assembly.
CLINT1 is also known as CLINT, ENTH, EPN4, EPNR.
Associated Diseases
- Parkinson disease
- multiple sclerosis
- Alzheimer disease
- lysosomal storage disease
- type 1 diabetes mellitus
