CLPTM1L
Description
The CLPTM1L (CLPTM1 like) is a protein-coding gene located on chromosome 5.
The CLPTM1L gene encodes the Cleft lip and palate transmembrane protein 1-like protein (CLPTM1L), also known as cisplatin resistance-related protein 9 (CRR9p). CLPTM1L is associated with cisplatin-induced apoptosis and its overexpression has been linked to lung tumor development and resistance to apoptosis caused by genotoxic agents. This resistance is associated with increased levels of the anti-apoptotic protein Bcl-xL. Inhibition of CLPTM1L has been shown to suppress oncogenic transformation and tumorigenesis induced by the KRas oncogene, potentially through the PI3K/Akt survival signaling pathway. CLPTM1L is located within a cancer susceptibility locus on chromosome 5 (5p15.33).
CLPTM1L is a lipid scramblase that facilitates the movement of glucosaminylphosphatidylinositol (GlcN-PI) across the endoplasmic reticulum (ER) membrane. This process is crucial for the synthesis of glycosylphosphatidylinositol (GPI), a lipid glycoconjugate involved in protein modification. Additionally, CLPTM1L can translocate phosphatidylinositol (PI) and other phospholipids, including 1,2-diacyl-sn-glycero-3-phosphocholine, 1,2-diacyl-sn-glycero-3-phosphoethanolamine, and N-acetylglucosaminylphosphatidylinositol (GlcNAc-PI), in vitro.
CLPTM1L is also known as CRR9.
