CMTM4
Description
The CMTM4 (CKLF like MARVEL transmembrane domain containing 4) is a protein-coding gene located on chromosome 16.
CMTM4 serves as a backup for CMTM6 in controlling the presence of PD-L1/CD274 on the cell surface. PD-L1/CD274 is an important immune checkpoint molecule that helps maintain tolerance to the body's own tissues and prevents the immune system from attacking tumors. CMTM4 might protect PD-L1/CD274 from being marked for destruction by preventing its polyubiquitination.
CMTM4 is also known as CKLFSF4.
Associated Diseases
- male infertility with teratozoospermia due to single gene mutation
- partial chromosome Y deletion
- spermatogenic failure 65
- spermatogenic failure, X-linked, 3
- spermatogenic failure 40
- spermatogenic failure 51
- spermatogenic failure 47
- spermatogenic failure 39
- spermatogenic failure 10
- spermatogenic failure 11
- spermatogenic failure 72
- spermatogenic failure 41
- spermatogenic failure 46
