CORIN
Description
The CORIN (corin, serine peptidase) is a protein-coding gene located on chromosome 4.
Corin, also known as atrial natriuretic peptide-converting enzyme, is a protein encoded by the CORIN gene in humans. It is a polypeptide of 1042 amino acids with a complex structure, including an N-terminal cytoplasmic domain, a transmembrane domain, and an extracellular region with multiple domains. Corin is synthesized as a zymogen and activated by PCSK6. Its primary function is to convert the precursor of atrial natriuretic peptide (ANP), pro-ANP, into mature ANP, a hormone that regulates salt-water balance and blood pressure. In mice, corin deficiency leads to impaired pro-ANP processing and salt-sensitive hypertension. Corin may also function as a pro-brain-type natriuretic peptide convertase. In pregnant uteri, corin-mediated ANP production promotes spiral artery remodeling and trophoblast invasion.
Corin is a serine protease that plays a crucial role in the processing of atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP). It converts inactive pro-ANP and pro-BNP into their active forms, ANP and BNP(1-32), respectively, through proteolytic cleavage. This process regulates blood pressure in the heart and promotes natriuresis, diuresis, and vasodilation. Additionally, corin's cleavage of pro-ANP is involved in female pregnancy, promoting trophoblast invasion and spiral artery remodeling in the uterus. Corin also functions as a regulator of sodium reabsorption in the kidneys.
CORIN is also known as ATC2, CMH30, CRN, Lrp4, PEE5, TMPRSS10.
