CPNE1
Description
The CPNE1 (copine 1) is a protein-coding gene located on chromosome 20.
Copine-1 is a protein encoded by the CPNE1 gene in humans. It is a highly conserved calcium-dependent membrane-binding protein found in different eukaryotes. Copine-1 contains an integrin A domain and two N-terminal type II C2 domains, which act as calcium-dependent phospholipid binding motifs and are involved in cell signaling or membrane trafficking pathways. However, Copine-1 does not contain a predicted signal sequence or transmembrane domains. It may regulate molecular events at the interface of the cell membrane and cytoplasm.
Copine-1 is a calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes. It is involved in the TNF-alpha receptor signaling pathway in a calcium-dependent manner. Copine-1 exhibits calcium-dependent phospholipid binding properties and plays a role in neuronal progenitor cell differentiation, inducing neurite outgrowth via an AKT-dependent signaling cascade in a calcium-independent manner. Copine-1 may recruit target proteins to the cell membrane in a calcium-dependent manner and may function in membrane trafficking. It is involved in TNF-alpha-induced NF-kappa-B transcriptional repression by inducing endoprotease processing of the transcription factor NF-kappa-B p65/RELA subunit. It also induces endoprotease processing of NF-kappa-B p50/NFKB1, p52/NFKB2, RELB and REL.
CPNE1 is also known as COPN1, CPN1.
